Cinnamic acids and derivatives
AdipoGen Curcumin
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.38. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4, tumorigenesis and development Shh, Gli, metabolism PPARgamma, Nrf2, epigenetics HDACs, HATs, DNA methyltransferase I and microRNAs and inflammation NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX.
Medchemexpress LLC LASSBio-1135 | 852453-71-5 | 99.1% | 286.33 g·mol^-1 | C18H14N4 | 5 MG
LASSBio-1135 is an orally active TRPV1 antagonist with anti-inflammatory and analgesic activity. It moderately inhibits human PGHS-2 (IC50 = 18.5 μM) and has shown in vivo efficacy by reversing capsaicin-induced thermal hyperalgesia and reducing carrageenan-induced paw edema.
- Orally active TRPV1 antagonist.
- Moderate inhibition of human PGHS-2 (IC50 = 18.5 μM).
- Demonstrated in vivo efficacy in pain and inflammation models.
- High purity suitable for research applications.
- Molecular weight 286.33 g·mol^-1 and formula C18H14N4.
- Available in small research quantities for dosing studies.
- Stable when stored as powder at -20°C for extended periods.
eMolecules 7345-79-1 | trans-2-Bromocinnamic Acid | MFCD00016836 | 25g
Ambeed | trans-2-Bromocinnamic Acid | 25g | 600846962 | A747884 | 7345-79-1 | MFCD00016836 | 227.057 | C9H7BrO2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Medchemexpress LLC Trans-4-chlorocinnamic acid | 1615-02-7 | MFCD00004396 | >98.0% | 182.60 g/mol | C9H7ClO2 | 100g
4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A) 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0 477 mM and 0 229 mM respectively 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol[1][2][3][4]
eMolecules 2062-25-1 | 2-(Trifluoromethyl)cinnamicacid | MFCD00004381 | 25g
Pharmablock | ethyl (1E)-N-(246-trimethylphenyl)sulfonyloxyethanimidate | 2.5g | 794216768 | PBT1480 | 38202-27-6 | MFCD00009244 | 285.360 | C13H19NO4S
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
TARGETMOL CHEMICALS INC TYRPHOSTIN AG1296 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 uM no activity to EGFR. purity: 99%
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g/mol | C10H6N2O | 50 MG
Tyrphostin 8 is a small-molecule research compound that acts as a weak epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor and a more potent inhibitor of the serine/threonine phosphatase calcineurin. Supplied as a solid for laboratory research, it is intended for research use only.
- Small-molecule inhibitor of EGFR and calcineurin (EGFR IC50 560 μM; calcineurin IC50 21 μM).
- High purity: 98.0%.
- Chemical formula C10H6N2O; molecular weight 170.17 g/mol.
- CAS number 3785-90-8.
- Soluble in DMSO at ≥ 100 mg/mL.
- Appearance: light yellow to yellow solid.
- Storage: store at 4°C under nitrogen; in solvent store at -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical applications.
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g·mol⁻¹ | C10H6N2O | 1 ML
Tyrphostin 8 is a small-molecule inhibitor that targets tyrosine kinases and GTPases and also inhibits calcineurin phosphatase activity. It is supplied at high purity for use in biochemical and cellular assays; chemical identifiers include CAS 3785-90-8, formula C10H6N2O, and molecular weight 170.17 g·mol⁻¹.
eMolecules 160434-49-1 | 3-Bromo-4-fluorocinnamic acid | Ambeed | MFCD00143095 | 245.047 | C9H6BrFO2 | 98.000 | OC(=O)\C=C\c1ccc(F)c(Br)c1 | 1g | 527443839
3-Bromo-4-fluorocinnamic acid | Ambeed | 160434-49-1 | MFCD00143095 | 245.047 | C9H6BrFO2 | 98.000 | OC(=O)\C=C\c1ccc(F)c(Br)c1 | 1g | 527443839
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 25mg
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
Medchemexpress LLC Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide | 866602-52-0 | 98.5% | 247.38 | C16H25NO | 5mg
Dodeca-2E 4E 8Z 10Z/E-N-tetraenoic acid isobutylamide is a brain-penetrant substance and the main alkamide in Echinacea preparations which might be used for research of common cold and various upper respiratory infections[1]
Accela Chembio Inc 4-hydroxy-3 | 5-dimethoxycinnamic Acid | Predominantly Trans | 100g | 530-59-6 | MFCD00004401 | 97+% | Shelf Life: 1080 Days | Light Sensitive
4-hydroxy-3 | 5-dimethoxycinnamic Acid | Predominantly Trans | 100g | 530-59-6 | MFCD00004401 | 97+% | Shelf Life: 1080 Days | Light Sensitive
Medchemexpress LLC MRL-494 hydrochloride | 2699937-04-5 | 98.6% | 50 MG
MRL-494 hydrochloride is an antibacterial agent that functions as an inhibitor of β-barrel assembly machine A (BamA), making it impervious to efflux and the outer membrane permeability barrier. It is effective against both Gram-positive and Gram-negative bacteria, with an MIC of 12.5 μM for *Staphylococcus aureus* COL and 25 μM for *E. coli* JCM158.
- Inhibits β-barrel assembly machine A (BamA)
- Impervious to efflux and the outer membrane permeability barrier
- Exhibits strong activity against both Gram-positive and Gram-negative bacteria
- Lethally disrupts the cytoplasmic membrane
- Inhibits outer membrane proteins (OMPs) biogenesis